| Protein Name | C-C motif chemokine receptor 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1234 |
| Gene Symbol | CCR5 |
| UniProt | P51681 (CCR5_HUMAN), Q38L21 (Q38L21_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
579
Total Number of Articles : 815 |
Description |
C-C motif chemokine receptor 5 |
| Gene Summary |
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015] |
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