Pub. Date : 2014 Jul
PMID : 25073400
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats. | scutellarin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 2 | OBJECTIVE: To investigate the influence of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 in rats in vivo. | scutellarin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 3 | The activity of CYP2C11 in rats was inhibited significantly after treatment with scutellarin by increased tolbutamide t1/2 (16.74%, P < 0.01), T(max) (116.87%, P < 0.05), C(max) (63.78%, P < 0.01) and AUC(0-infinity) (70.61%, P < 0.01) in the scutellarin-treated group compared with those of the blank control. | scutellarin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 4 | The activity of CYP2C11 in rats was inhibited significantly after treatment with scutellarin by increased tolbutamide t1/2 (16.74%, P < 0.01), T(max) (116.87%, P < 0.05), C(max) (63.78%, P < 0.01) and AUC(0-infinity) (70.61%, P < 0.01) in the scutellarin-treated group compared with those of the blank control. | scutellarin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 5 | CONCLUSION: Scutellarin could significantly inhibit CYP1A2, CYP2C11 and CYP3A1/2 activities in rats in vivo, but had no effects on the activity of CYP2D1. | scutellarin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |