Title : Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.

Pub. Date : 2015 Jan

PMID : 25069801






1 Functional Relationships(s)
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1 AITC-mediated reduction in the transcriptional activity of PXR and CAR correlated well with the suppression of CYP3A4 and CYP2B6 expression in HepG2 cells, which reflected the reduced catalytic activities of both of these genes following AITC treatment in differentiated HepaRG cells. allyl isothiocyanate cytochrome P450 family 3 subfamily A member 4 Homo sapiens