Title : Ligand binding and activation of PPARĪ³ by FiremasterĀ® 550: effects on adipogenesis and osteogenesis in vitro.

Pub. Date : 2014 Nov

PMID : 25062436






3 Functional Relationships(s)
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1 Solvent mapping was used to model TPP in the PPARgamma binding site. triphenyl phosphate peroxisome proliferator activated receptor gamma Homo sapiens
2 RESULTS: FM550 bound human PPARgamma, and binding appeared to be driven primarily by TPP. triphenyl phosphate peroxisome proliferator activated receptor gamma Homo sapiens
3 Solvent mapping revealed that TPP interacted with binding hot spots within the PPARgamma ligand binding domain. triphenyl phosphate peroxisome proliferator activated receptor gamma Homo sapiens