Title : Both JNK and P38 MAPK pathways participate in the protection by dexmedetomidine against isoflurane-induced neuroapoptosis in the hippocampus of neonatal rats.

Pub. Date : 2014 Aug

PMID : 25026397






3 Functional Relationships(s)
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1 Both JNK and P38 MAPK pathways participate in the protection by dexmedetomidine against isoflurane-induced neuroapoptosis in the hippocampus of neonatal rats. Isoflurane mitogen-activated protein kinase 8 Rattus norvegicus
2 Isoflurane induced significant neuroapoptosis, increased the protein expression of phospho-JNK, phospho-c-Jun, phospho-p38 and phospho-nuclear factor-kappaB (NF-kappaB), decreased the level of phospho-ERK1/2 protein and reduced the ratio of Bcl-2/Bax in the hippocampus. Isoflurane mitogen-activated protein kinase 8 Rattus norvegicus
3 Our results indicate that the JNK and p38 pathways, not the ERK pathway are involved in dexmedetomidine-induced neuroprotection against isoflurane effects. Isoflurane mitogen-activated protein kinase 8 Rattus norvegicus