Pub. Date : 2014 Jul 15
PMID : 25024815
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIM: To determine if other molecules reported to modulate AMP-dependent protein kinase (AMPK) activity would have effects resembling those of metformin and phenformin on colon cancer cell proliferation and metabolism. | Phenformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | AIM: To determine if other molecules reported to modulate AMP-dependent protein kinase (AMPK) activity would have effects resembling those of metformin and phenformin on colon cancer cell proliferation and metabolism. | Phenformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | RESULTS: Investigations with several molecules that have been reported to be associated with AMPK activation (A-769662, 5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside, EGCG, KU-55933, quercetin, resveratrol and salicylates) or AMPK inhibition (compound C) failed to reveal increased medium acidification and increased glucose uptake in colon cancer cells as previously established with metformin and phenformin. | Phenformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |