Title : Combined SFK/mTOR inhibition prevents rapamycin-induced feedback activation of AKT and elicits efficient tumor regression.

Pub. Date : 2014 Sep 1

PMID : 25023728






1 Functional Relationships(s)
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1 Addition of the Src/c-Abl inhibitor, dasatinib, completely blocks this feedback activation, confirming convergence between Src and the mTOR pathway. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens