Title : The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice.

Pub. Date : 2014 Jul 15

PMID : 25022542






1 Functional Relationships(s)
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1 We show that Retnla upregulates cholesterol-7-alpha-hydroxylase, a key hepatic enzyme in the cholesterol catabolic pathway, through induction of its transcriptional activator liver receptor homologue-1, leading to increased excretion of cholesterol in the form of bile acids. Cholesterol cytochrome P450, family 7, subfamily a, polypeptide 1 Mus musculus