Title : Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.

Pub. Date : 2014 Dec

PMID : 25016220

1 Functional Relationships(s)
Compound Name
Protein Name
1 The mechanism, underlying TSH-induced liver triglyceride accumulation, involved that TSH, through its receptor TSHR, triggered hepatic SREBP-1c activity via the cAMP/PKA/PPARalpha pathway associated with decreased AMPK, which further increased the expression of genes associated with lipogenesis. Triglycerides peroxisome proliferator activated receptor alpha Mus musculus