Pub. Date : 2014 Jul 1
PMID : 24988354
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this work, we characterize the aggregation process of human insulin at acidic pH in the presence of sulfate ions using a combination of Thioflavin T fluorescence, dynamic light scattering, size exclusion chromatography, Fourier transform infrared spectroscopy, and transmission electron microscopy. | Sulfates | insulin | Homo sapiens |
| 2 | It is found that the increase of sulfate concentration inhibits the conversion of insulin molecules into aggregates by modifying the aggregation pathway. | Sulfates | insulin | Homo sapiens |
| 3 | When the sulfate concentration is increased above 5 mM, the sulfate anion induces the salting-out of ~18-20% of insulin molecules into reversible amorphous aggregates, which retain a large content of alpha-helix structures. | Sulfates | insulin | Homo sapiens |