Pub. Date : 1989 Apr
PMID : 2497500
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intracisternal injection of thyrotropin-releasing hormone (TRH)-Gly (pGlu-His-Pro-Gly) produced a dose-dependent (1-100 micrograms) stimulation of gastric acid secretion in urethane-anesthetized rats implanted acutely with a gastric fistula. | Glycine | thyrotropin releasing hormone | Rattus norvegicus |
| 2 | Intracisternal injection of thyrotropin-releasing hormone (TRH)-Gly (pGlu-His-Pro-Gly) produced a dose-dependent (1-100 micrograms) stimulation of gastric acid secretion in urethane-anesthetized rats implanted acutely with a gastric fistula. | Glycine | thyrotropin releasing hormone | Rattus norvegicus |
| 3 | Thereafter, TRH values are returned to basal levels at 75 min after the injection, whereas TRH-Gly concentrations remain significantly elevated throughout the 2-h period of measurement. | Glycine | thyrotropin releasing hormone | Rattus norvegicus |
| 4 | Medullary coronal sections containing the dorsal vagal complex and the raphe nucleus revealed increased content of TRH-Gly, but not TRH, 40 min after administration of TRH-Gly at an intracisternal dose effective in stimulating gastric acid secretion (100 micrograms). | Glycine | thyrotropin releasing hormone | Rattus norvegicus |
| 5 | These data suggest that the intracisternal TRH-Gly-induced stimulation of gastric acid secretion is not related to its conversion to TRH in the CSF, or direct activation of TRH receptors in the medulla. | Glycine | thyrotropin releasing hormone | Rattus norvegicus |