Title : Transition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanine.

Pub. Date : 2014 Jul

PMID : 24966350






1 Functional Relationships(s)
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1 Specifically, we determined kinetic parameters for dCTP insertion opposite a chemically stable m7dG analogue, 2"-fluoro-m7dG (Fm7dG), by human DNA polymerase beta (polbeta) and solved three X-ray structures of polbeta in complex with the templating Fm7dG paired with incoming dCTP or dTTP analogues. 2'-deoxycytidine 5'-triphosphate DNA polymerase beta Homo sapiens