Title : HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability.

Pub. Date : 2014 Jun 26

PMID : 24965120






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Redox-sensitive kinase; PYK2 activation led to increased tyrosine phosphorylation of VE-cadherin and beta-catenin, leading to disruption of junctional assembly. Tyrosine catenin beta 1 Homo sapiens
2 The dissociation of tyrosine phosphatases VE-PTP and SHP2 from cadherin complex resulted into increased tyrosine phosphorylation of VE-cadherin and beta-catenin in HIV-1 Tat C treated hBMVECs. Tyrosine catenin beta 1 Homo sapiens