Title : Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the phosphatidylinositol 3-kinase/protein kinase B pathway.

Pub. Date : 2014 Aug 17

PMID : 24960055






1 Functional Relationships(s)
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1 Taken together, HBCD and PCBs at low concentrations could increase the resistance of HCC cells to cisplatin through modulation on NF-kappaB pathway activation and p53 function, which is associated with the activity of PI3K/Akt pathway. Cisplatin nuclear factor kappa B subunit 1 Homo sapiens