Pub. Date : 2014 Jul
PMID : 24959268
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anticancer activities of sulindac in prostate cancer cells associated with c-Jun NH2-terminal kinase 1/beta-catenin signaling. | Sulindac | catenin beta 1 | Homo sapiens |
| 2 | Further studies revealed that sulindac significantly induces c-Jun NH2-terminal kinase (JNK) 1 phosphorylation and inhibits beta-catenin at the transcriptional and post-transcriptional levels. | Sulindac | catenin beta 1 | Homo sapiens |
| 3 | In conclusion, by targeting the JNK1/beta-catenin signaling pathway, sulindac may present a potential preventive or therapeutic agent for treatment of patients with prostate cancer. | Sulindac | catenin beta 1 | Homo sapiens |