Pub. Date : 2014 Sep
PMID : 24956021
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG. | icariin | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | It was found that icariin dose-dependently increased ALP activity, and treatment at the optimal concentration (10(-5)M) increased NOS activity, iNOS and eNOS expression, NO production, sGC and cGMP contents and PKG expression besides the phosphorylation of AKT. | icariin | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | These results suggest that the osteogenic effect of icariin involves the PI3K-AKT-eNOS-NO-cGMP-PKG signal pathway. | icariin | AKT serine/threonine kinase 1 | Rattus norvegicus |