Pub. Date : 2014 Sep
PMID : 24953041
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). | Dinoprostone | epidermal growth factor receptor | Homo sapiens |
| 2 | In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). | Dinoprostone | epidermal growth factor receptor | Homo sapiens |
| 3 | In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). | Dinoprostone | epidermal growth factor receptor | Homo sapiens |
| 4 | In human renal proximal tubular HK2 cells, prostaglandin E2 (PGE2) up-regulates HIF-1alpha and VEGF-A through epidermal growth factor receptor (EGFR)-dependent up-regulation of retinoic acid receptor-beta (RARbeta). | Dinoprostone | epidermal growth factor receptor | Homo sapiens |
| 5 | Treatment of HK2 cells with PGE2 resulted in increased phosphorylation of EGFR, the three studied kinases and the histone H3 (Ser10) at the RARbeta gene promoter (the latter has been proposed as a molecular signature of the activated RARbeta gene promoter). | Dinoprostone | epidermal growth factor receptor | Homo sapiens |
| 6 | Prevention of the phosphorylation of EGFR, ERK1/2, p38 MAPK or MSK1 is by incubating, respectively, with AG1478, PD98059, SB203580 or H89 allowed to elucidate the precise phosphorylation order in the signaling cascade triggered by PGE2: first, EGFR; then, ERK1/2 and p38 MAPK and, finally, MSK1. | Dinoprostone | epidermal growth factor receptor | Homo sapiens |