Pub. Date : 2014 Aug 25
PMID : 24952354
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sulforaphane induces autophagy through ERK activation in neuronal cells. | sulforaphane | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Here, we provide evidence that SFN induces autophagy with increased levels of LC3-II through extracellular signal-regulated kinase (ERK) activation in neuronal cells. | sulforaphane | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Here, we provide evidence that SFN induces autophagy with increased levels of LC3-II through extracellular signal-regulated kinase (ERK) activation in neuronal cells. | sulforaphane | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Pretreatment with NAC (N-acetyl-l-cysteine), a well-known antioxidant, completely blocked the SFN-induced increase in LC3-II levels and activation of ERK. | sulforaphane | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Together, the results suggest that SFN-mediated generation of reactive oxygen species (ROS) induces autophagy via ERK activation, independent of Nrf2 activity in neuronal cells. | sulforaphane | mitogen-activated protein kinase 1 | Homo sapiens |