Title : Atorvastatin increases lipopolysaccharide-induced expression of tumour necrosis factor-α-induced protein 8-like 2 in RAW264.7 cells.

Pub. Date : 2014 Jul

PMID : 24944625






2 Functional Relationships(s)
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1 Atorvastatin significantly increased LPS induced expression of TIPE2, downregulated the expression of NOS, COX-2, MIF and NF-kappaB and the production of PGE2, NO, IL-6 and TNF-alpha in a time and dose dependent manner, and increased HO-1 protein expression, reduced ROS production in a dose dependent manner. Atorvastatin interleukin 6 Mus musculus
2 The observations indicated that atorvastatin upregulated LPS induced expression of TIPE2 and consequently inhibited MIF, NF-kappaB, NOS and COX-2 expression and the production of NO, PGE2, TNF-alpha and IL-6, increased HO-1 expression, and inhibited ROS activity in cultured RAW264.7 cells. Atorvastatin interleukin 6 Mus musculus