Pub. Date : 2014 Oct
PMID : 24934751
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AP-1 activation attenuates the arsenite-induced apoptotic response in human bronchial epithelial cells by up-regulating HO-1 expression. | arsenite | heme oxygenase 1 | Homo sapiens |
| 2 | Here, we show that a significant induction of HO-1 expression is present in human bronchial epithelial cells (Beas-2B) treated with lethal doses of arsenite treatment. | arsenite | heme oxygenase 1 | Homo sapiens |
| 3 | As expected, HO-1 RNAi knockdown, or ERK/AP1 inhibition, renders the Beas-2B cells more sensitive to arsenite damage. | arsenite | heme oxygenase 1 | Homo sapiens |
| 4 | Our data thus suggest that transcriptional upregulation of HO-1 expression via a putative ERK/AP-1 pathway constitutes an inherent mechanism by which arsenite-induced apoptosis is attenuated. | arsenite | heme oxygenase 1 | Homo sapiens |