Title : Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.

Pub. Date : 2014 Sep

PMID : 24930757






2 Functional Relationships(s)
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1 Finally, the generation of ROS was required for CHOP and DR5 up-regulation by ilimaquinone. ros TNF receptor superfamily member 10b Homo sapiens
2 These results demonstrate that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimaquinone could be developed into an adjuvant chemotherapeutic drug. ros TNF receptor superfamily member 10b Homo sapiens