Title : Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.

Pub. Date : 2014 Jun 24

PMID : 24927551






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 During accurate repair in nonmutating cells, uracil is excised by uracil DNA glycosylase (UNG), leaving abasic sites that are incised by AP endonuclease (APE) to create single-strand breaks, and the correct nucleotide is reinserted by DNA polymerase beta. Uracil apurinic/apyrimidinic endonuclease 1 Mus musculus
2 During accurate repair in nonmutating cells, uracil is excised by uracil DNA glycosylase (UNG), leaving abasic sites that are incised by AP endonuclease (APE) to create single-strand breaks, and the correct nucleotide is reinserted by DNA polymerase beta. Uracil apurinic/apyrimidinic endonuclease 1 Mus musculus