Protein Name apurinic/apyrimidinic endonuclease 1
Organism Mus musculus
Gene ID 11792
Gene Symbol

Apex1

UniProt P28352 (APEX1_MOUSE), Q544Z7 (Q544Z7_MOUSE)
Relationships Total Number of functionally related compound(s) : 70
Total Number of Articles : 54
Description

apurinic/apyrimidinic endonuclease 1

Gene Summary

Predicted to enable several functions, including DNA binding activity; NF-kappaB binding activity; and nuclease activity. Acts upstream of or within cell redox homeostasis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; autopod; early conceptus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • DNA repair nuclease/redox regulator APEX1
  • AP endonuclease 1
  • APEN
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Properties