Title : Pathogenic role of ganglioside metabolism in neurodegenerative diseases.

Pub. Date : 2014 Oct

PMID : 24903509






1 Functional Relationships(s)
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1 In lipid rafts, interactions of glycosphingolipids, including ganglioside, with proteins may be responsible for the misfolding events that cause the fibril and/or aggregate processing of disease-specific proteins, such as alpha-synuclein, in Parkinson"s disease, huntingtin protein in Huntington"s disease, and copper-zinc superoxide dismutase in amyotrophic lateral sclerosis. Gangliosides synuclein alpha Homo sapiens