Title : Molecular mechanisms of converting K562/DNR cellular drug-resistance by bortezomib.

Pub. Date : 2014

PMID : 24899604






4 Functional Relationships(s)
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1 OBJECTIVES: The aim of this study was to observe the effects of bortezomib (PS341) on the expression of NF-kappaB (nuclear factor-kappa B), IkappaB (inhibitor kB) and P-gp (P-glycoprotein) of K562 cells induced by daunorubicin (K562/DNR). Bortezomib ATP binding cassette subfamily B member 1 Homo sapiens
2 OBJECTIVES: The aim of this study was to observe the effects of bortezomib (PS341) on the expression of NF-kappaB (nuclear factor-kappa B), IkappaB (inhibitor kB) and P-gp (P-glycoprotein) of K562 cells induced by daunorubicin (K562/DNR). Bortezomib ATP binding cassette subfamily B member 1 Homo sapiens
3 When K562/DNR were cultured with bortezomib, the expressions of NF-kappaB and P-gp induced by DNR were significantly suppressed and this effcet increased with the increase of the concentration or the action time of bortezomib. Bortezomib ATP binding cassette subfamily B member 1 Homo sapiens
4 When K562/DNR were cultured with bortezomib, the expressions of NF-kappaB and P-gp induced by DNR were significantly suppressed and this effcet increased with the increase of the concentration or the action time of bortezomib. Bortezomib ATP binding cassette subfamily B member 1 Homo sapiens