Title : Binding of the Kaposi's sarcoma-associated herpesvirus to the ephrin binding surface of the EphA2 receptor and its inhibition by a small molecule.

Pub. Date : 2014 Aug

PMID : 24899181






5 Functional Relationships(s)
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1 We describe here that natural ephrin ligands inhibit the gH/gL-EphA2 interaction. glycylleucine EPH receptor A2 Homo sapiens
2 The effects of point mutations within EphA2 demonstrated that KSHV gH/gL interacts with EphA2 through a restricted set of the same residues that mediate binding of A-type ephrins. glycylleucine EPH receptor A2 Homo sapiens
3 The effects of point mutations within EphA2 demonstrated that KSHV gH/gL interacts with EphA2 through a restricted set of the same residues that mediate binding of A-type ephrins. glycylleucine EPH receptor A2 Homo sapiens
4 Two previously described inhibitors of the EphA2 interaction with ephrin A5 also inhibited binding of KSHV gH/gL to EphA2. glycylleucine EPH receptor A2 Homo sapiens
5 Two previously described inhibitors of the EphA2 interaction with ephrin A5 also inhibited binding of KSHV gH/gL to EphA2. glycylleucine EPH receptor A2 Homo sapiens