Title : CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells.

Pub. Date : 2014 Nov

PMID : 24890801






2 Functional Relationships(s)
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1 In turn, the sub-G1 fraction was dominated in CYP3A4-overexpressing cells following C-1305 exposure. C 1305 cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Conversely, cellular response was modulated following C-1305 treatment in CYP3A4-overexpressing cells, although metabolism of this drug was unaltered. C 1305 cytochrome P450 family 3 subfamily A member 4 Homo sapiens