Pub. Date : 2014 May 7
PMID : 24886428
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A PKC-SHP1 signaling axis desensitizes Fcgamma receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcgammaR mediated phagocytosis. | Tyrosine | Cbl proto-oncogene | Homo sapiens |
| 2 | It is well-known that Fcgamma receptor (FcgammaR) crosslinking induces the tyrosine phosphorylation of CBL which is associated with FcgammaR mediated phagocytosis, however how signaling molecules coordinate to desensitize these receptors is unclear. | Tyrosine | Cbl proto-oncogene | Homo sapiens |
| 3 | RESULTS: Using the U937IF cell line, we observed that FcgammaR1 crosslinking induces the tyrosine phosphorylation of CBL, which is maximal at 5 min. | Tyrosine | Cbl proto-oncogene | Homo sapiens |
| 4 | These findings suggest a mechanism for Fcgamma receptor desensitization by which a serine-threonine kinase e.g. PKC downregulates tyrosine phosphorylation dependent signaling events via the reduced tyrosine phosphorylation of the complex adapter protein, CBL. | Tyrosine | Cbl proto-oncogene | Homo sapiens |
| 5 | These findings suggest a mechanism for Fcgamma receptor desensitization by which a serine-threonine kinase e.g. PKC downregulates tyrosine phosphorylation dependent signaling events via the reduced tyrosine phosphorylation of the complex adapter protein, CBL. | Tyrosine | Cbl proto-oncogene | Homo sapiens |