Title : Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity?

Pub. Date : 2014 May 21

PMID : 24885036






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We recently found that RSV administration to SOD1G93A mice preserves spinal MN function and increases mice survival. Resveratrol superoxide dismutase 1, soluble Mus musculus
2 The main goal of this work was to assess the effect of combined RSV and PRE-084 administration in SOD1G93A ALS mice. Resveratrol superoxide dismutase 1, soluble Mus musculus
3 CONCLUSIONS: Although combined PRE and RSV treatment significantly ameliorated SOD1G93A mice, it did not show a synergistic effect compared to RSV-only and PRE-084-only treated groups. Resveratrol superoxide dismutase 1, soluble Mus musculus