Title : Inhibition of food intake by PACAP in the hypothalamic ventromedial nuclei is mediated by NMDA receptors.

Pub. Date : 2014 Jun 22

PMID : 24878316






2 Functional Relationships(s)
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1 Furthermore, PACAP administration into the VMN resulted in increased tyrosine phosphorylation of the GluN2B subunit of the NMDA receptor, and inhibition of Src kinase activity also blocked the effects of PACAP administration into the VMN on feeding behavior. Tyrosine adenylate cyclase activating polypeptide 1 Homo sapiens
2 These results indicate that PACAP neurotransmission in the VMN likely augments glutamate signaling by potentiating NMDA receptors activity through the tyrosine phosphorylation events mediated by the Src kinase family, and modulation of NMDA receptor activity by PACAP in the hypothalamus may be a primary mechanism for its regulation of food intake. Tyrosine adenylate cyclase activating polypeptide 1 Homo sapiens