Title : Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits.

Pub. Date : 2014 Jun 17

PMID : 24850492






4 Functional Relationships(s)
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1 RESULTS: Frontal white matter myo-inositol was elevated in subjects with HIV across the age span but showed age-dependent increase in seronegative subjects, especially in APOE epsilon4+ carriers. Inositol apolipoprotein E Homo sapiens
2 In contrast, only seronegative APOE epsilon4+ subjects showed elevated myo-inositol in parietal cortex. Inositol apolipoprotein E Homo sapiens
3 Higher myo-inositol levels were associated with poorer fine motor function across all subjects, slower speed of information processing in APOE epsilon4+ subjects, and worse fluency in HIV+ APOE epsilon4+ subjects. Inositol apolipoprotein E Homo sapiens
4 Higher myo-inositol levels were associated with poorer fine motor function across all subjects, slower speed of information processing in APOE epsilon4+ subjects, and worse fluency in HIV+ APOE epsilon4+ subjects. Inositol apolipoprotein E Homo sapiens