Title : A conserved motif in the linker domain of STAT1 transcription factor is required for both recognition and release from high-affinity DNA-binding sites.

Pub. Date : 2014

PMID : 24847715

1 Functional Relationships(s)
Compound Name
Protein Name
1 In contrast, two glutamic acid residues (E559 and E563) on each monomer are important for the dissociation of dimeric STAT1 from DNA and, when mutated to alanine, result in elevated levels of tyrosine-phosphorylated STAT1 as well as prolonged IFNgamma-stimulated nuclear accumulation. Tyrosine interferon gamma Homo sapiens