Title : Melatonin rescues 3T3-L1 adipocytes from FFA-induced insulin resistance by inhibiting phosphorylation of IRS-1 on Ser307.

Pub. Date : 2014 Aug

PMID : 24846082






2 Functional Relationships(s)
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1 Following a preincubation with melatonin or vehicle for 30 min, insulin resistant cells of 3T3-L1 adipocytes were induced by palmitic acids (300 muM, 6 h). Palmitic Acids insulin Homo sapiens
2 Our results showed that palmitic acids inhibited both the basal and insulin-stimulated uptake of [(3)H]-2-Deoxyglucose, down-regulated the levels of IRS-1 and GLUT-4. Palmitic Acids insulin Homo sapiens