Pub. Date : 2014 Jun 3
PMID : 24843120
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center. | Iron | poly(rC) binding protein 1 | Homo sapiens |
| 2 | Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center. | Iron | poly(rC) binding protein 1 | Homo sapiens |
| 3 | Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A. | Iron | poly(rC) binding protein 1 | Homo sapiens |
| 4 | Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A. | Iron | poly(rC) binding protein 1 | Homo sapiens |
| 5 | Cells depleted of PCBP1 or PCBP2 exhibited loss of DOHH activity and loss of the holo form of the enzyme in cells, particularly when cells were made mildly iron-deficient. | Iron | poly(rC) binding protein 1 | Homo sapiens |
| 6 | PCBP1 bound to DOHH in iron-treated cells but not in control or iron-deficient cells. | Iron | poly(rC) binding protein 1 | Homo sapiens |
| 7 | Thus, PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells. | Iron | poly(rC) binding protein 1 | Homo sapiens |
| 8 | Thus, PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells. | Iron | poly(rC) binding protein 1 | Homo sapiens |
| 9 | Thus, PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells. | Iron | poly(rC) binding protein 1 | Homo sapiens |