Pub. Date : 2014 Jul 1
PMID : 24837423
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The hypothesis of a system is supported by (i) coordinate regulation of subsets of these enzyme families and transporters by transcription factors including the AhR, and (ii) feedback loops between endobiotic AhR agonists and substrates of major catabolic target genes/proteins; for example, 6-formylindolo[3,2-b]carbazole as substrate of CYP1A1, and bilirubin, as substrate of UGT1A1. | Bilirubin | aryl hydrocarbon receptor | Homo sapiens |
| 2 | The hypothesis of a system is supported by (i) coordinate regulation of subsets of these enzyme families and transporters by transcription factors including the AhR, and (ii) feedback loops between endobiotic AhR agonists and substrates of major catabolic target genes/proteins; for example, 6-formylindolo[3,2-b]carbazole as substrate of CYP1A1, and bilirubin, as substrate of UGT1A1. | Bilirubin | aryl hydrocarbon receptor | Homo sapiens |
| 3 | In the latter case the AhR is one of multiple transcription factors contributing to bilirubin homeostasis. | Bilirubin | aryl hydrocarbon receptor | Homo sapiens |