Title : Effects of enoxaparin on myeloperoxidase release during hemodialysis.

Pub. Date : 2014 Oct

PMID : 24837008






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1 Effects of enoxaparin on myeloperoxidase release during hemodialysis. Enoxaparin myeloperoxidase Homo sapiens
2 We studied if low-molecular-weight heparin enoxaparin administered for hemodialysis (HD) anticoagulation causes systemic MPO activation. Enoxaparin myeloperoxidase Homo sapiens
3 Plasma MPO levels were measured in patients undergoing maintenance HD with an intravenous bolus of enoxaparin. Enoxaparin myeloperoxidase Homo sapiens
4 During enoxaparin-anticoagulated HD plasma MPO levels strikingly increased in all patients (8.6-fold at 10 minutes and 3.3-fold at 120 minutes, both P < 0.0001). Enoxaparin myeloperoxidase Homo sapiens
5 Enoxaparin administered for HD anticoagulation induces a marked and dose-dependent increase in plasma MPO as a plausibly favorable result of the liberation of the enzyme from the vascular wall. Enoxaparin myeloperoxidase Homo sapiens