Title : Metabolic activation of pyrrolizidine alkaloids: insights into the structural and enzymatic basis.

Pub. Date : 2014 Jun 16

PMID : 24836403






2 Functional Relationships(s)
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1 Only CYP3A4 and CYP3A5 activated otonecine-type PAs, while all 10 CYPs studied showed the ability to activate retronecine-type PAs. Pyrrolizidine Alkaloids cytochrome P450 family 3 subfamily A member 5 Homo sapiens
2 Only CYP3A4 and CYP3A5 activated otonecine-type PAs, while all 10 CYPs studied showed the ability to activate retronecine-type PAs. Pyrrolizidine Alkaloids cytochrome P450 family 3 subfamily A member 5 Homo sapiens