Title : Thiol-PEG-carboxyl-stabilized Fe₂O ₃/Au nanoparticles targeted to CD105: synthesis, characterization and application in MR imaging of tumor angiogenesis.

Pub. Date : 2014 Jul

PMID : 24832501






9 Functional Relationships(s)
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1 Characteristics of the hybrid-PEG-CD105 nanoparticles were evaluated. Polyethylene Glycols endoglin Mus musculus
2 RESULTS: The mean diameter of the hybrid-PEG-CD105 nanoparticles was 56.6 +- 8.0 nm, as measured by transmission electron microscopy (TEM). Polyethylene Glycols endoglin Mus musculus
3 Immune activity of the hybrid-PEG-CD105 nanoparticles was 53% of that of the anti-CD105 antibody, as detected by enzyme-linked immunosorbent assay (ELISA). Polyethylene Glycols endoglin Mus musculus
4 Immune activity of the hybrid-PEG-CD105 nanoparticles was 53% of that of the anti-CD105 antibody, as detected by enzyme-linked immunosorbent assay (ELISA). Polyethylene Glycols endoglin Mus musculus
5 The specific binding of HUVECs with the hybrid-PEG-CD105 nanoparticles was proved by immunostaining and Prussian blue staining in vitro. Polyethylene Glycols endoglin Mus musculus
6 For breast cancer xenografts, the combination of the hybrid-PEG-CD105 nanoparticles with blood microvessels was detectable by MRI after 60 min administration of the contrast agent. Polyethylene Glycols endoglin Mus musculus
7 CONCLUSION: Anti-CD105 antibody-coupled, thiol-PEG-carboxyl-stabilized core-shell Fe2O3/Au nanoparticles can efficiently target CD105 expressed by HUVECs. Polyethylene Glycols endoglin Mus musculus
8 CONCLUSION: Anti-CD105 antibody-coupled, thiol-PEG-carboxyl-stabilized core-shell Fe2O3/Au nanoparticles can efficiently target CD105 expressed by HUVECs. Polyethylene Glycols endoglin Mus musculus
9 Furthermore, the hybrid-PEG-CD105 nanoparticles can be used to detect tumor angiogenesis in vivo. Polyethylene Glycols endoglin Mus musculus