Pub. Date : 2015 Mar
PMID : 24824874
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To elucidate the roles of sulfide in inflammation, we have investigated its interactions with human myeloperoxidase (MPO), a major contributor to inflammatory oxidative stress. | Sulfides | myeloperoxidase | Homo sapiens |
| 2 | To elucidate the roles of sulfide in inflammation, we have investigated its interactions with human myeloperoxidase (MPO), a major contributor to inflammatory oxidative stress. | Sulfides | myeloperoxidase | Homo sapiens |
| 3 | Sulfide was a potent reversible inhibitor of MPO enzymic activity with an IC50 of 1 microM. | Sulfides | myeloperoxidase | Homo sapiens |
| 4 | In addition, the measured second-order rate constants for the reactions of sulfide with compound I [k = (1.1 +- 0.06) x 10(6) M(-1) s(-1)] and compound II [k = (2.0 +- 0.03) x 10(5) M(-1) s(-1)] suggest that sulfide is a potential substrate for MPO in vivo. | Sulfides | myeloperoxidase | Homo sapiens |
| 5 | CONCLUSION AND IMPLICATIONS: Endogenous levels of sulfide are likely to inhibit the activity of circulating and endothelium-bound MPO. | Sulfides | myeloperoxidase | Homo sapiens |