Title : Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice.

Pub. Date : 2015 Jan

PMID : 24824608






1 Functional Relationships(s)
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1 Analysis of liver leukocytes by flow cytometry revealed that emigrated neutrophils up-regulated TLR9 expression during acetaminophen-mediated necrosis, and these cells sensed and reacted to extracellular DNA by activating the TLR9/NF-kappaB pathway. Acetaminophen nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus