Pub. Date : 2014 Aug 1
PMID : 24812010
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acrolein decreases endothelial cell migration and insulin sensitivity through induction of let-7a. | Acrolein | insulin | Homo sapiens |
| 2 | Exposure to acrolein attenuated beta3 integrin-dependent migration and reduced Akt phosphorylation in response to insulin. | Acrolein | insulin | Homo sapiens |
| 3 | These effects of acrolein on endothelial cell migration and insulin signaling were reversed by expression of a let-7a inhibitor. | Acrolein | insulin | Homo sapiens |
| 4 | Also, inhalation exposure of mice to acrolein (1 ppm x 6 h/day x 4 days) upregulated let-7a and led to a decrease in insulin-stimulated Akt phosphorylation in the aorta. | Acrolein | insulin | Homo sapiens |