Pub. Date : 2014 Jul
PMID : 24807198
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MiR-101, downregulated in retinoblastoma, functions as a tumor suppressor in human retinoblastoma cells by targeting EZH2. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 2 | Finally, we found that miR-101 directly inhibited EZH2 expression by targeting its 3"-UTR, and EZH2 was upregulated and inversely correlated with miR-101 expression in the retinoblastoma tissues. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 3 | Finally, we found that miR-101 directly inhibited EZH2 expression by targeting its 3"-UTR, and EZH2 was upregulated and inversely correlated with miR-101 expression in the retinoblastoma tissues. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 4 | Thus, for the first time, we provide convincing evidence that downregulation of miR-101 is associated with tumor aggressiveness in retinoblastoma and inhibits cell growth and proliferation of retinoblastoma cells by targeting EZH2. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |