Title : In vitro inhibitory effects of scutellarin on six human/rat cytochrome P450 enzymes and P-glycoprotein.

Pub. Date : 2014 May 5

PMID : 24802986






1 Functional Relationships(s)
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1 Results demonstrated that scutellarin showed negligible inhibitory effects on the six major CYP isoenzymes in human/rat liver microsomes with almost all of the IC50 values exceeding 100 muM, whereas it showed values of 63.8 muM for CYP2C19 in human liver microsomes, and 63.1 and 85.6 muM for CYP2C7 and CYP2C79 in rat liver microsomes, respectively. scutellarin cytochrome P450 family 4 subfamily F member 3 Homo sapiens