Pub. Date : 2014 Jul 25
PMID : 24802810
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western blot analysis showed that UA promoted the phosphorylation of PERK and eIF2alpha; this was followed by the upregulation of the downstream protein CHOP, implying the involvement of the ER stress-mediated PERK/eIF2alpha/CHOP pathway in glioma cells. | ursolic acid | eukaryotic translation initiation factor 2 alpha kinase 3 | Homo sapiens |
| 2 | Western blot analysis showed that UA promoted the phosphorylation of PERK and eIF2alpha; this was followed by the upregulation of the downstream protein CHOP, implying the involvement of the ER stress-mediated PERK/eIF2alpha/CHOP pathway in glioma cells. | ursolic acid | eukaryotic translation initiation factor 2 alpha kinase 3 | Homo sapiens |
| 3 | Furthermore, TUDCA and the silencing of either PERK or IRE1alpha partially blocked the UA-induced accumulation of LC3-II, suggesting that ER stress precedes the process of autophagy. | ursolic acid | eukaryotic translation initiation factor 2 alpha kinase 3 | Homo sapiens |