Pub. Date : 2014 Jun 15
PMID : 24799565
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that treatment of macrophages with the pan caspase inhibitor (zVAD-FMK) results in both increased phosphorylation and decreased cleavage of receptor interacting protein kinase-1 (Rip1), leading to necroptosis that is dependent on autocrine TNF signaling. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | receptor interacting serine/threonine kinase 1 | Homo sapiens |
| 2 | We show that treatment of macrophages with the pan caspase inhibitor (zVAD-FMK) results in both increased phosphorylation and decreased cleavage of receptor interacting protein kinase-1 (Rip1), leading to necroptosis that is dependent on autocrine TNF signaling. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | receptor interacting serine/threonine kinase 1 | Homo sapiens |
| 3 | Stimulation of cells with TLR agonists such as LPS in the presence of zVAD-FMK also induced Rip1-phosphorylation via a TNFR-independent mechanism. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | receptor interacting serine/threonine kinase 1 | Homo sapiens |