Title : Sorafenib metabolism is significantly altered in the liver tumor tissue of hepatocellular carcinoma patient.

Pub. Date : 2014

PMID : 24797816






2 Functional Relationships(s)
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1 BACKGROUND: Sorafenib, the drug used as first line treatment for hepatocellular carcinoma (HCC), is metabolized by cytochrome P450 (CYP) 3A4-mediated oxidation and uridine diphosphate glucuronosyl transferase (UGT) 1A9-mediated glucuronidation. Sorafenib cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 BACKGROUND: Sorafenib, the drug used as first line treatment for hepatocellular carcinoma (HCC), is metabolized by cytochrome P450 (CYP) 3A4-mediated oxidation and uridine diphosphate glucuronosyl transferase (UGT) 1A9-mediated glucuronidation. Sorafenib cytochrome P450 family 4 subfamily F member 3 Homo sapiens