Title : Alpha-lipoic acid protects against cisplatin-induced ototoxicity via the regulation of MAPKs and proinflammatory cytokines.

Pub. Date : 2014 Jun 27

PMID : 24796665






1 Functional Relationships(s)
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1 ALA pretreatment significantly reduced apoptotic cell death of the inner and outer hair cells in cisplatin-treated organ of Corti explants and attenuated ototoxicity via marked inhibition of the increase in the expression of IL-1beta and IL-6, the phosphorylation of ERK and p38, the degradation of IkappaBalpha, the increase in intracellular levels of ROS, and the activation of caspase-3 in cisplatin-treated HEI-OC1 cells. Cisplatin mitogen-activated protein kinase 14 Homo sapiens