Title : Metformin inhibits nuclear factor-κB activation and inflammatory cytokines expression induced by high glucose via adenosine monophosphate-activated protein kinase activation in rat glomerular mesangial cells in vitro.

Pub. Date : 2014

PMID : 24791887






2 Functional Relationships(s)
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1 Both genes and protein expression of NF-kappaB, MCP-1, ICAM-1, TGF-beta1 of MCs induced by high glucose were markedly reduced after metformin treatment in a dose-dependent manner (P < 0.05). Metformin intercellular adhesion molecule 1 Rattus norvegicus
2 Conlusion Metformin can suppress the expression of NF-kappaB, MCP-1, ICAM-1 and TGF-beta1 of glomerular MCs induced by high glucose via AMPK activation, which may partly contribute to its reno-protection. Metformin intercellular adhesion molecule 1 Rattus norvegicus