Protein Name intercellular adhesion molecule 1
Organism Rattus norvegicus
Gene ID 25464
Gene Symbol

Icam1

UniProt Q00238 (ICAM1_RAT)
Relationships Total Number of functionally related compound(s) : 647
Total Number of Articles : 894
Description

intercellular adhesion molecule 1

Gene Summary

Enables integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • intercellular adhesion molecule 1
  • ICAM-1
  • CD54
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Properties