Pub. Date : 1989
PMID : 2478821
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | One of the earliest documented events following incubation of these cells with Ang II is the rapid, phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate to yield two second messengers, inositol trisphosphate and diacylglycerol. | Diglycerides | angiotensinogen | Homo sapiens |
| 2 | Inositol trisphosphate releases calcium from nonmitochondrial intracellular storage sites, while diacylglycerol activates protein kinase C. Ang II also stimulates calcium influx and increases calcium efflux for the duration of the stimulus, as well as causing a biphasic change in intracellular pH. | Diglycerides | angiotensinogen | Homo sapiens |